Menace of Bhendi Yellow Vein Mosaic Virus (BYVMV) disease drastically reduces the yield and quality of the bhendi, Abelmoschus esculentus L Moench. To alleviate this problem, Neem Insecticidal Soap (NIS @ 2%) a laboratory formulation was prepared and its efficacy was evaluated along with Neem Azal 0.6 % (Parry India Ltd), Neem gold 0.6% (Spic, India), Achook 0.6% (Godrej Agrovet Ltd, India), Rogar 0.05% (30 Ec Dimethoate) under field conditions. Disease incidence noticed in control plot was 46% while the Neem Azal, Rogar, Neem gold, Achook and NIS applied plots were 21, 20, 19, 18 and 17%, respectively. The maximum percentage of fruit yield was obtained from the field treated with NIS (59.26 q/ha), whereas, the minimum yield was recorded in control (53 .25 q/ha) as well as in neem gold treated fields (53.31 q/ha). Thus, the use of NIS has been considered as cheap, ecofriendly and effective for controlling Bhendi yellow vein mosaic virus (BYVMV) consequently optimize their yield.