Ashwagandha is considered as an important medicinal crop in Indian system of medicine. Ashwagandha suffers attack by several insect pests. The mealy bug, Coccidohystrix insolitus (Green.) and spotted leaf beetle, Epilachna vigintioctopunctata Fab. are found to be the key pests. Since Ashwagandha is a herbal medicine, application of synthetic chemicals leads accumulation of toxic residues. Field experiments were conducted with application of farmyard manure (FYM) (12.5 t/ha) + Azophos (2 kg/ha) + neem cake (1000 kg/ha) and need based foliar application of neem oil (3%) were found to be very effective in reducing the incidence of mealy bug and the damage of spotted leaf beetle.