The use of chemical pesticide and other agro chemicals are getting reduced /being banned globally because of their toxic effects on human beings and his live stock, residual toxicity, environmental problems, pest out-breaks and drastic effects on beneficial insects. Therefore, now it is imperative to develop a holistic system of tackling pests to make it more eco-friendly, economically viable and socially acceptable for the farmers. In the WTO regime, it is absolutely necessary to limit the usage of chemicals, to remain in the world market and sustain the competition. In this regard to tackle the major pests and diseases of major crops biotechnological approaches are gaining momentum. Compared with usage of chemical pesticides biopesticides constitute around 2% in the country. The biotechnological approaches of pest control such as use of botanical pesticides, use of microbial pesticides, augmentative biocontrol by inundative releases, pheromones and attractants in pest management and plant incorporated protectants (PIPs) / GM crops which are discussed in detail. Advantages and limitations of biopesticides have been outlined and the future approaches are highlighted.