Field trials conducted on integrated disease management practices to combat major diseases and to increase the seed yield of sesame during summer 2009 and 2010 revealed that soil application of neem cake (250 kg/ha) along with seed treatment and soil application (2.5 kg/ha) of Trichoderma viride followed by foliar spray of azadirachtin @ 3 mL/L on 30 and 45 DAS (Module 3) was found to be significantly effective by recording minimum disease incidence coupled with maximum seed yield with higher cost benefit (C:B) ratio. Though module M2 and M1 ranked next to M3 with statistically on par in reducing the diseases, the module M2 consists of seed treatment and soil application (2.5 kg/ha) of T. viride followed by foliar spray of mancozeb (0.25%) + endosulfan (0.07%) on 30 and 45 DAS significantly different from M1 by recording seed yield and C: B ratio. All the modules were superior over farmer’s practices (without any treatment)