This paper deals about the application of SIR (Systemic Induced Resistance) chemicals and organic sources like Panchakavya to the host along with Bio control agent would enhance disease suppressing mechanisms against rice blast disease. Among the various treatments, seed treatment of Pseudomonas fluorescens (PFS) a native isolation @ 10 g/kg of seeds along Annamalai nagar with foliar application of chemical Nicotinic acid NA1 (15 DAT- days after transplanting @ 100 ppm) and organic product “Panchakavya” (Modified) PK2 (30 DAT @ 5 %) increased plant height, Number of tillers, Number of productive tillers per clump, panicle length, thousand grain weight and minimum disease incidence recorded in IR 50 under pot culture conditions. Percentage of filled grain, grain yield and straw yield are improved when compared to other treatments. Also, Seed and foliar application of bio protectant increased the rhizosphere population.